Invention Grant
- Patent Title: Combined CGH and allele specific hybridisation method
- Patent Title (中): 组合CGH和等位基因特异性杂交方法
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Application No.: US13520935Application Date: 2011-01-07
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Publication No.: US09587278B2Publication Date: 2017-03-07
- Inventor: Douglas Hurd , Edwin Southern
- Applicant: Douglas Hurd , Edwin Southern
- Applicant Address: GB Oxfordshire
- Assignee: OXFORD GENE TECHNOLOGY (OPERATIONS) LTD.
- Current Assignee: OXFORD GENE TECHNOLOGY (OPERATIONS) LTD.
- Current Assignee Address: GB Oxfordshire
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: GB1000315.0 20100108; GB1006438.4 20100416; GB1014226.3 20100825
- International Application: PCT/GB2011/000012 WO 20110107
- International Announcement: WO2011/083312 WO 20110714
- Main IPC: C12Q1/68
- IPC: C12Q1/68

Abstract:
The invention combines the fields of comparative genomic hybridization (CGH) analysis and SNP array analysis. It relates to methods for detecting and mapping genetic abnormalities associated with various diseases. In particular the invention provides a method for simultaneously performing array CGH and SNP array analysis on a genomic DNA sample comprising contacting a nucleic acid array which comprises a first probe set and a second probe set with a genomic DNA sample, comprising a test and reference sample, under hybridization conditions, comparing the amount of test sample and reference sample hybridized to the hybridization probes of the first probe set, comparing the amount of test sample and reference sample hybridized to the hybridization probes of the second probe set; and using the data obtained to determine the copy number of at least one locus; and at least one SNP in the genomic DNA sample.
Public/Granted literature
- US20130102476A1 COMBINED CGH & ALLELE SPECIFIC HYBRIDISATION METHOD Public/Granted day:2013-04-25
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