A system, in certain embodiments, includes a centrifugal compressor diffuser including a flow path having a first surface and a second surface defining opposite axial sides of the flow path. The centrifugal compressor diffuser also includes multiple vanes extending from the first surface to the second surface of the flow path. A first profile of each vane varies along an axial direction. The centrifugal compressor diffuser further includes multiple vanelets extending from the first surface toward the second surface in the axial direction. A first axial extent of each vanelet is less than a second axial extent of the flow path. In addition, a second profile of each vanelet varies along the axial direction and/or the vanelets form a non-periodic pattern around a circumference of the flow path.