Invention Grant
- Patent Title: In vitro method of inhibiting the growth of radioresistant laryngeal cancer cells
- Patent Title (中): 抑制放射抗性喉癌细胞生长的体外方法
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Application No.: US14746859Application Date: 2015-06-23
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Publication No.: US09588119B2Publication Date: 2017-03-07
- Inventor: Jae-Sung Kim , Sang-Gu Hwang , Young-Hoon Han
- Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
- Applicant Address: KR Seoul
- Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
- Current Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
- Current Assignee Address: KR Seoul
- Agency: Revolution IP, PLLC
- Priority: KR10-2014-0145085 20141024
- Main IPC: G01N33/574
- IPC: G01N33/574 ; C12N15/113
Abstract:
Disclosed are increased expression of ERp57, ERp57-STAT3 complex, and ERp57-STAT3-Mcl-1 in laryngeal cancer, especially in radioresistant laryngeal cancer and their regulations on radioresistance of laryngeal cancer. As such, the efficacy of radiotherapy can be enhanced by diagnosing prognosis in laryngeal cancer and radioresistance of laryngeal cancer. Furthermore, provided are a method of screening a therapeutic agent for laryngeal cancer including selecting a candidate drug that inhibits the expression of ERp57 or inactivates ERp57, and a therapeutic method for inhibiting or treating laryngeal cancer or radioresistant laryngeal cancer, thereby being useful in the treatment of laryngeal cancer.
Public/Granted literature
- US20160116473A1 METHOD OF DIAGNOSING LARYNGEAL CANCER OR DIAGNOSING PROGNOSIS IN RADIORESISTANCE OF LARYNGEAL CANCER Public/Granted day:2016-04-28
Information query
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