A method for performing multi-slice MR Elastography on an anatomical region of interest associated with a patient includes inducing shear waves at a shear wave frequency value (e.g., between 25-500 Hz) in the anatomical region of interest using an external driver. Next, the anatomical region of interest is imaged during a single patient breath-hold using an MRI acquisition process. Following the MRI acquisition process(es), phase images of the anatomical region of interest are generated based on an acquired RF signal. These phase images may then be processed (e.g., using an inversion algorithm) to generate one or more quantitative images depicting stiffness of the anatomical region of interest. In some embodiments, a wave image is also generated showing propagation of the plurality of shear waves through the anatomical region of interest based on the phase images.