An apparatus for interference cancellation includes: a front end processing circuit, for receiving at least an interference signal and a desire signal; an inner processing circuit, for channel/noise estimation and for suppressing the interference signal; and a MIMO (multi-input multi-output) processing circuit, for blindly detecting an interference parameter of the interference signal based on the suppressed interference signal, and for jointly cancelling the interference signal from the desire signal and for demodulating the desire signal based on the detected interference parameter and the channel/noise estimation from the inner processing circuit.