Audio transmitter circuitry is disclosed that is configurable into different modes by the user, and can output either a differential or single-ended audio signal on two signal wires. Depending on the mode, the transmitter deals with noise on the signal wires by adjusting the input resistance that such noise sees looking into the transmitter. If the transmitter is configured in a differential mode, the input resistance looking back into the transmitter from the perspective of the noise on both signal wires is relatively high. If the transmitter is configured in a single ended mode, the input resistance of noise looking back from the active signal wire into the transmitter is relatively low, to in effect ground such noise back into the transmitter, without significantly presenting such noise to the receiver.