A method for and apparatus for transmitting and receiving data in a wireless communication system supporting multiple carriers is provided. A wireless device determines a starting OFDM symbol of a physical downlink shared chancel (PDSCH) which is variably located by presence of reference signal (RS), a number of physical resource block (PRB)s used for an enhanced physical downlink control channel (ePDCCH), and receives the ePDCCH. The ePDCCH is set by one or more sets of PRBs within the PDSCH configured for a UE to monitor the ePDCCH. Thus, more efficient and accurate scheduling with lower complexity and reduction of control overhead of a master cell (as PCell), for multi-UEs and variable control information transmissions are supported in this invention.