A wheat variety designated W050216N2, the plants and seeds of wheat variety W050216N2, methods for producing a wheat plant produced by crossing the variety W050216N2 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety W050216N2 with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety W050216N2. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety W050216N2 and to wheat varieties or breeding lines produced by those methods.