Invention Grant
- Patent Title: Genetically modified major histocompatibility complex animals
- Patent Title (中): 转基因主要组织相容性复合动物
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Application No.: US13793812Application Date: 2013-03-11
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Publication No.: US09591835B2Publication Date: 2017-03-14
- Inventor: Lynn MacDonald , Andrew J. Murphy , Cagan Gurer , John McWhirter , Vera Voronina , Faith Harris , Sean Stevens , Yingzi Xue
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Brownstein Hyatt Farber Schreck, LLP
- Agent Rita S. Wu; Margarita Zippin
- Main IPC: A01K67/027
- IPC: A01K67/027 ; A01K67/00
Abstract:
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
Public/Granted literature
- US20130185819A1 Genetically Modified Major Histocompatibility Complex Animals Public/Granted day:2013-07-18
Information query
