Invention Grant
US09592259B2 APC-mediated tolerance induction for therapy of multiple sclerosis
有权
APC介导的多发性硬化症治疗耐受诱导
- Patent Title: APC-mediated tolerance induction for therapy of multiple sclerosis
- Patent Title (中): APC介导的多发性硬化症治疗耐受诱导
-
Application No.: US14347439Application Date: 2012-09-26
-
Publication No.: US09592259B2Publication Date: 2017-03-14
- Inventor: Christiane Dresch , Bruna de Andrade Pereira , Mathias Ackermann , Cornel Fraefel
- Applicant: Universität Zürich Prorektorat MNW
- Applicant Address: CH Zürich
- Assignee: University of Zurich
- Current Assignee: University of Zurich
- Current Assignee Address: CH Zürich
- Agency: Dinsmore & Shohl L.L.P.
- Agent Weston R. Gould
- Priority: EP11182700 20110926
- International Application: PCT/EP2012/068954 WO 20120926
- International Announcement: WO2013/045488 WO 20130404
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61K48/00 ; A61K35/76 ; A61K31/10 ; A61K35/12 ; C12N15/11 ; A61K31/711 ; A61K38/16 ; C07K14/47
Abstract:
The invention relates to transgene expression constructs—particularly self inactivating lentiviral vectors—comprising a dendritic cell specific promoter controlling the expression of autoantigen proteins, namely myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein, for use in the therapy of multiple sclerosis.
Public/Granted literature
- US20140242037A1 APC-MEDIATED TOLERANCE INDUCTION FOR THERAPY OF MULTIPLE SCLEROSIS Public/Granted day:2014-08-28
Information query
IPC分类:
