Invention Grant
US09592288B2 Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
有权
将少突胶质细胞前体细胞定向分化为髓鞘细胞命运
- Patent Title: Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
- Patent Title (中): 将少突胶质细胞前体细胞定向分化为髓鞘细胞命运
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Application No.: US13985342Application Date: 2012-02-17
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Publication No.: US09592288B2Publication Date: 2017-03-14
- Inventor: Peter Schultz , Luke Lairson , Vishal Deshmukh , Costas Lyssiotis
- Applicant: Peter Schultz , Luke Lairson , Vishal Deshmukh , Costas Lyssiotis
- Applicant Address: US CA La Jolla BM Hamilton
- Assignee: The Scripps Research Institute,IRM LLC
- Current Assignee: The Scripps Research Institute,IRM LLC
- Current Assignee Address: US CA La Jolla BM Hamilton
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2012/025712 WO 20120217
- International Announcement: WO2012/112933 WO 20120823
- Main IPC: A61K31/5415
- IPC: A61K31/5415 ; A61K31/135 ; A61K31/137 ; A61K31/138 ; A61K31/40 ; A61K31/439 ; A61K39/395 ; A61K38/21
Abstract:
The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.
Public/Granted literature
- US20140038949A1 DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE Public/Granted day:2014-02-06
Information query
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