Invention Grant
US09593106B2 Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists
有权
哌啶-1-基和吖庚因-1-基羧酸盐作为毒蕈碱M4受体激动剂
- Patent Title: Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists
- Patent Title (中): 哌啶-1-基和吖庚因-1-基羧酸盐作为毒蕈碱M4受体激动剂
-
Application No.: US14766520Application Date: 2014-02-07
-
Publication No.: US09593106B2Publication Date: 2017-03-14
- Inventor: David Livermore , Kathryn White , Miles Congreve , Giles Brown , Michael O'Brien
- Applicant: Heptares Therapeutics Limited
- Applicant Address: GB Welwyn Garden
- Assignee: Heptares Therapeutics Limited
- Current Assignee: Heptares Therapeutics Limited
- Current Assignee Address: GB Welwyn Garden
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Mei Bai
- International Application: PCT/GB2014/050371 WO 20140207
- International Announcement: WO2014/122474 WO 20140814
- Main IPC: A61K31/4523
- IPC: A61K31/4523 ; C07D401/14 ; C07D417/14 ; C07D413/14 ; C07D409/14 ; A61K31/454 ; A61K31/4545 ; A61K31/506 ; A61K31/55 ; A61K45/06
Abstract:
The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases such as schizophrenia, Alzheimer's disease and various cognitive disorders as well as in the treatment or alleviation of pain.
Public/Granted literature
- US20150376179A1 PIPERIDIN-1 -YL AND AZEPIN-1 -YL CARBOXYLATES AS MUSCARINIC M4 RECEPTOR AGONISTS Public/Granted day:2015-12-31
Information query
IPC分类:
