Invention Grant
US09593113B2 Imide and acylurea derivatives as modulators of the glucocorticoid receptor
有权
酰胺和酰基脲衍生物作为糖皮质激素受体的调节剂
- Patent Title: Imide and acylurea derivatives as modulators of the glucocorticoid receptor
- Patent Title (中): 酰胺和酰基脲衍生物作为糖皮质激素受体的调节剂
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Application No.: US14911485Application Date: 2014-08-21
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Publication No.: US09593113B2Publication Date: 2017-03-14
- Inventor: David S. Weinstein , Hua Gong , Michael G Yang , Zili Xiao
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2014/052014 WO 20140821
- International Announcement: WO2015/027021 WO 20150226
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D311/90 ; C07D311/80 ; C07D491/04
Abstract:
Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-KB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a pharmaceutically-acceptable salt thereof, in which the variables are as defined in the specification.
Public/Granted literature
- US20160185776A1 IMIDE AND ACYLUREA DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR Public/Granted day:2016-06-30
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