Invention Grant
US09593128B2 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
有权
四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
- Patent Title: Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
- Patent Title (中): 四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
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Application No.: US14151680Application Date: 2014-01-09
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Publication No.: US09593128B2Publication Date: 2017-03-14
- Inventor: Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Linchin Feng , Minmin Yang
- Applicant: Michael Patrick Dillon , Ronald Charles Hawley , Li Chen , Linchin Feng , Minmin Yang
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Main IPC: C07D257/04
- IPC: C07D257/04 ; C07D498/08 ; C07D401/10 ; C07D403/10 ; C07D403/14 ; C07D405/12 ; C07D407/10 ; C07D413/10 ; C07D417/10 ; C07D491/10 ; C07D241/12 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D409/12 ; C07D417/12 ; C07D471/04 ; C07D491/107
Abstract:
Compounds of the formula V: or a pharmaceutically acceptable salt thereof, wherein, R2 is optionally substituted phenyl, optionally substituted pyridin-2-yl or optionally substituted thienyl, and R3, R4, R5, R6 and R13 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
Public/Granted literature
- US20150191487A1 TETRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS Public/Granted day:2015-07-09
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