Invention Grant
- Patent Title: Nitrile-containing enzyme inhibitors and ruthenium complexes thereof
- Patent Title (中): 含腈的酶抑制剂及其钌络合物
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Application No.: US13998148Application Date: 2013-10-07
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Publication No.: US09593138B2Publication Date: 2017-03-14
- Inventor: Jeremy J. Kodanko , Claudia Turro
- Applicant: Wayne State University , Ohio State Innovation Foundation
- Applicant Address: US MI Detroit US OH Columbus
- Assignee: Wayne State University,Ohio State Innovation Foundation
- Current Assignee: Wayne State University,Ohio State Innovation Foundation
- Current Assignee Address: US MI Detroit US OH Columbus
- Agency: Billion & Armitage
- Agent Patti J. Jurkovich
- Main IPC: C07F15/00
- IPC: C07F15/00
Abstract:
The invention provides nitrile-containing protease inhibitors caged to ruthenium compounds. The nitrile-caged ruthenium compounds provide inactivated inhibitors that can be delivered to surface or site for activation, for example, but exposure to light. The invention also provides methods for delivering protease inhibitors to subjects for the therapeutic treatment of conditions such as cancer.
Public/Granted literature
- US20140100173A1 Nitrile-containing enzyme inhibitors and ruthenium complexes thereof Public/Granted day:2014-04-10
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