Invention Grant
US09593159B2 Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses
有权
能够中和系统发育组1和系统发育组2和乙型流感病毒的甲型流感病毒的人结合分子
- Patent Title: Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses
- Patent Title (中): 能够中和系统发育组1和系统发育组2和乙型流感病毒的甲型流感病毒的人结合分子
-
Application No.: US14597016Application Date: 2015-01-14
-
Publication No.: US09593159B2Publication Date: 2017-03-14
- Inventor: Theodorus Hendrikus Kwaks , David Adrianus Theodorus Maria Zuijdgeest , Ronald Vogels , Robert H. E. Friesen
- Applicant: Crucell Holland B.V.
- Applicant Address: NL Leiden
- Assignee: Janssen Vaccines & Prevention B.V.
- Current Assignee: Janssen Vaccines & Prevention B.V.
- Current Assignee Address: NL Leiden
- Agency: TraskBritt, P.C.
- Priority: EP11173953 20110714
- Main IPC: A61K39/42
- IPC: A61K39/42 ; C07K16/10 ; G01N33/569 ; A61K39/00
Abstract:
Described are binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. Provided are nucleic acid molecules encoding the binding molecules, their sequences, and compositions comprising the binding molecules. The binding molecules can be used, for example, in the diagnosis, prophylaxis, and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.
Public/Granted literature
Information query
