Invention Grant
US09593161B2 Humanization of rabbit antibodies using a universal antibody framework
有权
使用通用抗体框架对兔抗体进行人源化
- Patent Title: Humanization of rabbit antibodies using a universal antibody framework
- Patent Title (中): 使用通用抗体框架对兔抗体进行人源化
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Application No.: US14179141Application Date: 2014-02-12
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Publication No.: US09593161B2Publication Date: 2017-03-14
- Inventor: Leonardo Jose Borras , David Urech
- Applicant: ESBATech, an Alcon Biomedical Research Unit LLC
- Applicant Address: CH
- Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
- Current Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
- Current Assignee Address: CH
- Main IPC: C07K16/18
- IPC: C07K16/18 ; C07K16/22 ; C07K16/24
Abstract:
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
Public/Granted literature
- US20140221624A1 HUMANIZATION OF RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK Public/Granted day:2014-08-07
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