Invention Grant
- Patent Title: Wnt pathway stimulation in reprogramming somatic cells with nuclear reprogramming factors
- Patent Title (中): Wnt通路刺激重编程体细胞与核重编程因子
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Application No.: US14822653Application Date: 2015-08-10
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Publication No.: US09593311B2Publication Date: 2017-03-14
- Inventor: Brett Chevalier , Alexander Marson , Richard A. Young , Ruth Foreman , Rudolf Jaenisch
- Applicant: Whitehead Institute for Biomedical Research
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Morse, Barnes-Brown & Pendleton, P.C.
- Agent Lisa M. Warren, Esq.
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N5/074
Abstract:
The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
Public/Granted literature
- US20160068819A1 WNT PATHWAY STIMULATION IN REPROGRAMMING SOMATIC CELLS WITH NUCLEAR REPROGRAMMING FACTORS Public/Granted day:2016-03-10
Information query
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