Invention Grant
- Patent Title: Binding molecules with antitumoral activity
- Patent Title (中): 结合分子具有抗肿瘤活性
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Application No.: US14385729Application Date: 2013-03-08
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Publication No.: US09593314B2Publication Date: 2017-03-14
- Inventor: Simon Brack , Frédéric Mourlane , Isabella Toller , Richard Woods , Julian Bertschinger , Dragan Grabulovski , Babette Schade , Kristina Klupsch , Helen Hachemi
- Applicant: Covagen AG
- Applicant Address: CH Schlieren
- Assignee: Covagen AG
- Current Assignee: Covagen AG
- Current Assignee Address: CH Schlieren
- Agency: Hunton & Williams LLP
- Priority: EP12159938 20120316
- International Application: PCT/EP2013/054768 WO 20130308
- International Announcement: WO2013/135588 WO 20130919
- Main IPC: C07K19/00
- IPC: C07K19/00 ; C07K16/40 ; C07K16/30 ; C12N9/12 ; A61K39/395 ; C07K16/32 ; A01K67/027 ; A61K39/00

Abstract:
The present invention relates to a binding molecule that specifically binds to two different epitopes of an antigen expressed on tumor cells, wherein the binding molecule comprises: (a) a first binding (poly)peptide that specifically binds to a first epitope of said antigen expressed on tumor cells, wherein said first binding (poly)peptide is a Fyn SH3-derived polypeptide; and (b) a second binding (poly)peptide that specifically binds to a second epitope of said antigen expressed on tumor cells. The present invention further relates to a nucleic acid molecule encoding the binding molecule of the invention, a vector comprising said nucleic acid molecule as well as a host cell or a non-human host transformed with said vector. The invention further relates to a method of producing a binding molecule of the invention as well as to pharmaceutical and diagnostic composition. Moreover, the present invention also relates to the binding molecule, the nucleic acid molecule, the vector or the host cell of the invention for use in the treatment of tumors.
Public/Granted literature
- US20150047065A1 NOVEL BINDING MOLECULES WITH ANTITUMORAL ACTIVITY Public/Granted day:2015-02-12
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