Invention Grant
US09593330B2 Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
有权
通过抑制FXN的天然反义转录物治疗frataxin（FXN）相关疾病
- Patent Title: Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
- Patent Title (中): 通过抑制FXN的天然反义转录物治疗frataxin（FXN）相关疾病
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Application No.: US14124886Application Date: 2012-06-08
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Publication No.: US09593330B2Publication Date: 2017-03-14
- Inventor: Joseph Collard , Olga Khorkova Sherman
- Applicant: Joseph Collard , Olga Khorkova Sherman
- Applicant Address: US FL Miami
- Assignee: CuRNA, Inc.
- Current Assignee: CuRNA, Inc.
- Current Assignee Address: US FL Miami
- Agency: CuRNA, Inc.
- Agent Monte R. Browder
- International Application: PCT/US2012/041484 WO 20120608
- International Announcement: WO2012/170771 WO 20121213
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K31/70 ; C12N15/113 ; C12N5/00
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Frataxin (FXN), in particular, by targeting natural antisense polynucleotides of Frataxin (FXN). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of FXN.
Public/Granted literature
- US20140187606A1 TREATMENT OF FRATAXIN (FXN) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO FXN Public/Granted day:2014-07-03
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