Invention Grant
US09593334B2 Use of the chromosome 19 microRNA cluster (C19MC) for treating viral disease and promoting authophagy
有权
使用染色体19微RNA簇（C19MC）治疗病毒性疾病和促进食管癌
- Patent Title: Use of the chromosome 19 microRNA cluster (C19MC) for treating viral disease and promoting authophagy
- Patent Title (中): 使用染色体19微RNA簇（C19MC）治疗病毒性疾病和促进食管癌
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Application No.: US14383222Application Date: 2013-03-06
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Publication No.: US09593334B2Publication Date: 2017-03-14
- Inventor: Yoel Sadovsky , Carolyn Coyne Candrilli
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2013/029420 WO 20130306
- International Announcement: WO2013/134416 WO 20130912
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N15/113
Abstract:
It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental recipient cells by exosome-mediated delivery of microRNAs (miRs). PHT cells express high levels of unique, primate-specific miRNAs, expressed from the chromosome 19 miRNA cluster (C19MC). It is further disclosed herein that C19MC miRNAs are packaged within PHT-derived exosomes and attenuate viral replication in recipient cells by inducing autophagy. Thus, provided herein are methods of inhibiting, treating or preventing microbial infections by administering one or more miRs of the C19MC. Also provided are methods of inducing autophagy in a cell by contacting the cell with one or more miRs of the C19MC.
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