Invention Grant
- Patent Title: Expression system for modulating an immune response
- Patent Title (中): 用于调节免疫反应的表达系统
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Application No.: US12738284Application Date: 2008-10-02
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Publication No.: US09593340B2Publication Date: 2017-03-14
- Inventor: Ian Hector Frazer , Julie Louise Dutton
- Applicant: Ian Hector Frazer , Julie Louise Dutton
- Applicant Address: AU Woolloongabba
- Assignee: Admedus Vaccines Pty Ltd.
- Current Assignee: Admedus Vaccines Pty Ltd.
- Current Assignee Address: AU Woolloongabba
- Agency: Cooley LLP
- International Application: PCT/AU2008/001463 WO 20081002
- International Announcement: WO2009/049350 WO 20090423
- Main IPC: C12N15/79
- IPC: C12N15/79 ; A61K39/145 ; A61K39/245 ; A61K39/29 ; C07K14/005 ; C12N15/67 ; C40B40/08 ; C40B50/04 ; A61K39/12 ; A61K39/00
Abstract:
The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response results from the expression of a polynucleotide that encodes at least a portion of the target antigen, wherein the quality is modulated by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower preference of usage by the mammal to confer the immune response than the codon it replaces.
Public/Granted literature
- US20110020374A1 EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE Public/Granted day:2011-01-27
Information query
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