Systems and methods for operating a thermoelectric module to increase efficiency are disclosed. In some embodiments, a method of operating a thermoelectric module includes determining a first amount of power that would maximize a coefficient of performance of the thermoelectric module based on one or more system parameters and providing the first amount of power to the thermoelectric module. The method also includes determining that at least one of the one or more system parameters has changed, determining a second amount of power that would maximize the coefficient of performance of the thermoelectric module based on the one or more system parameters, and providing the second amount of power to the thermoelectric module. In some embodiments, adjusting the amount of power provided based on the one or more system parameters increases the efficiency of the thermoelectric module.