Opto-electrical connection systems including opto-electrical cables providing configurable connectivity between electrical devices having electrical interfaces are disclosed. Related assemblies and methods are also disclosed. By using configurable connection assemblies having at least one configurable connection device adapted to accept optical connectors of optical fibers of opto-electrical cables, many electrical devices having electrical interfaces may be configurably connected. For example, the configurable opto-electrical connection system may be configured to provide more bandwidth and/or connect electrical devices with less power consumption than would be associated with conventional copper cabling solutions. In this manner, the high bandwidth, lower power consumption, and long distance signal capability of optical fibers may be provided to connect electronic devices which were originally designed with electrical interfaces meant to be connected with copper cables.