In one embodiment, a wheelchair drive mechanism adapted to mount to a wheelchair includes a drive lever adapted to be rotated forward and rearward by a user of the wheelchair, a clutch mechanism associated with the drive lever, wherein actuation of the clutch mechanism causes the drive lever to be coupled to a wheel of the wheelchair such that they rotate together, and a clutch actuation device provided on the drive lever that is operable by the wheelchair user to actuate the clutch mechanism.