Invention Grant
- Patent Title: Production of dentin, cementum and enamel by cells
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Application No.: US13877262Application Date: 2011-10-03
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Publication No.: US09597359B2Publication Date: 2017-03-21
- Inventor: Jeremy J. Mao , Mo Chen
- Applicant: Jeremy J. Mao , Mo Chen
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Dentons US LLP
- International Application: PCT/US2011/054663 WO 20111003
- International Announcement: WO2012/045097 WO 20120405
- Main IPC: A61K35/32
- IPC: A61K35/32 ; C12N5/077 ; C12N5/0775 ; C12N5/071 ; A61K35/28 ; A61K35/36 ; A61K35/51 ; A61K35/545 ; A23L33/10
Abstract:
Described is a method of forming a mineralized material by co-culturing epithelial cell, such as ameloblast, and mesenchymal cell, such as osteoblast or odontoblast, in a mineral-stimulating medium. Also described is a matrix seeded with epithelial cells and mesenchymal cells and infused with a mineral-stimulating medium capable of forming a mineralized material in the matrix. Methods of manufacturing such compositions and methods of treating mineralization-related conditions are also described.
Public/Granted literature
- US20140093481A1 PRODUCTION OF DENTIN, CEMENTUM AND ENAMEL BY CELLS Public/Granted day:2014-04-03
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