Invention Grant
- Patent Title: Oil-in-water emulsion influenza vaccine
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Application No.: US12596202Application Date: 2008-04-16
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Publication No.: US09597389B2Publication Date: 2017-03-21
- Inventor: William Ripley Ballou , Emmanuel Jules Hanon
- Applicant: William Ripley Ballou , Emmanuel Jules Hanon
- Applicant Address: BE Rixensart
- Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
- Current Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
- Current Assignee Address: BE Rixensart
- Agent Natalie A. Lissy
- Priority: GB0707697.9 20070420; GB0711357.4 20070612; GB0712062.9 20070621; WOPCT/EP2007/060743 20071010; GB0724651.5 20071218
- International Application: PCT/EP2008/054614 WO 20080416
- International Announcement: WO2008/128939 WO 20081030
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A61K39/12 ; A61K39/39 ; C12N7/00 ; A61K39/00

Abstract:
The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant composition comprising an oil-in-water emulsion, wherein said oil-in-water emulsion comprises a metabolisable oil at a level of below 11 mg and an emulsifying agent at a level of below 5 mg and optionally a tocol or a sterol at a level of below 12 mg. Suitably the amount of influenza antigen per strain per dose is 15 μg HA or a low amount such as less than 15 μg HA.
Public/Granted literature
- US20100189741A1 OIL-IN-WATER EMULSION INFLUENZA VACCINE Public/Granted day:2010-07-29
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