The invention provides a system for regenerative air purification and a method thereof. The system includes a set of gas sensors, a processor, an adsorption gas filters with TiO2 (or TiO2 mixed activated carbon material) coated on the outer surface, a set of auto valves, a set of UV lamps, and a heater near the adsorption filter. The processor is configured to receive input data from the gas sensors and to control the system. During an air cleaning phase, the air is ventilated through the adsorption filter and VOCs are trapped therein. During a regenerative phase, the UV lamps and heater are turned on and the adsorption filter media will be cleaned up via the combined approaches including the heating of the heater, photo-catalytic oxidation and a reversed air flow.