Systems and methods for efficiently collecting and disposing waste from disparate locations within a facility, the method including coupling a series of empty waste receptacles to a tow vehicle and transporting the receptacles to a first location. At the first location, identifying a first full waste receptacle and exchanging it with one of the empty receptacles coupled to the vehicle. The full waste receptacle and remaining empty receptacles are thereafter transported via the tow vehicle to a second location, where a second full waste receptacle is exchanged with one of the remaining empty receptacles. Thereafter, the first and second full waste receptacles are transported to a waste processing location. In some embodiments, the process may be repeated until all the empty waste receptacles on the vehicle have been exchanged with full waste receptacles, at which point the vehicle transports the full waste receptacles to the waste processing location.