- Patent Title: 3-(2-amino-ethyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-alkylidene-1,3-dihydro-indol-2-one derivatives as selective sphingosine kinase 2 inhibitors
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Application No.: US14933042Application Date: 2015-11-05
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Publication No.: US09598384B2Publication Date: 2017-03-21
- Inventor: Shijun Zhang , Sarah Spiegel
- Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
- Applicant Address: US VA Richmond
- Assignee: Virginia Commonwealth University
- Current Assignee: Virginia Commonwealth University
- Current Assignee Address: US VA Richmond
- Agency: Whitham, Curtis & Cook, P.C.
- Main IPC: C07D209/34
- IPC: C07D209/34 ; C07D209/44 ; C07D277/34
Abstract:
3-(2-amino-ethyl)-5-[3-(4-substituted-phenyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-3-alkylidene-1,3-dihydro-indol-2-one and derivatives thereof are provided for use as selective SphK2 inhibitors and for use in the treatment of human diseases, such as cancer.
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