Invention Grant
- Patent Title: Process for making reverse transcriptase inhibitors
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Application No.: US15100940Application Date: 2014-12-02
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Publication No.: US09598397B2Publication Date: 2017-03-21
- Inventor: Yang Cao , Donald R. Gauthier, Jr. , Guy R. Humphrey , Tetsuji Itoh , Michel Journet , Gang Qian , Benjamin D. Sherry , David M. Tschaen
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Carol S. Quagliato; Catherine D. Fitch
- International Application: PCT/US2014/068008 WO 20141202
- International Announcement: WO2015/084763 WO 20150611
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D213/69 ; C07D213/78
Abstract:
The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.
Public/Granted literature
- US20160297794A1 PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS Public/Granted day:2016-10-13
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