Invention Grant
- Patent Title: Imidazo[4,5-C]quinolines as DNA-PK inhibitors
-
Application No.: US14676125Application Date: 2015-04-01
-
Publication No.: US09598408B2Publication Date: 2017-03-21
- Inventor: Thomas Fuchss , Werner Mederski , Frank Zenke
- Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
- Applicant Address: DE Darmstadt
- Assignee: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
- Current Assignee: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano and Branigan, P.C.
- Priority: DE102010035744 20100828
- Main IPC: C07D417/04
- IPC: C07D417/04 ; C07D215/42 ; C07D215/44 ; C07D215/46 ; A61K31/437 ; A61K31/4745 ; A61K31/5377 ; C07D471/04 ; A61K45/06
![Imidazo[4,5-C]quinolines as DNA-PK inhibitors](/abs-image/US/2017/03/21/US09598408B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to compounds of the formulae (I) and (II) in which R1, R2, R3, R4, R5, R8, X and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I).
Public/Granted literature
- US20150203491A1 IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS Public/Granted day:2015-07-23
Information query