Invention Grant
- Patent Title: Inhibitors of IRAK4 activity
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Application No.: US14434344Application Date: 2013-10-03
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Publication No.: US09598440B2Publication Date: 2017-03-21
- Inventor: W. Michael Seganish , William T. McElroy , Stephanie Brumfield , R. Jason Herr , Larry Yet , Jinhai Yang , James P. Harding, III , Ginny Dai Ho , Deen Tulshian , Wensheng Yu , Michael K.C. Wong , Brian Lavey , Joseph A. Kozlowski
- Applicant: MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: MERCK SHARP & DOHME CORP.
- Current Assignee: MERCK SHARP & DOHME CORP.
- Current Assignee Address: US NJ Rahway
- Agent Matthew A. Leff; John C. Todaro
- International Application: PCT/US2013/063163 WO 20131003
- International Announcement: WO2014/058685 WO 20140417
- Main IPC: A61K31/444
- IPC: A61K31/444 ; A61K31/506 ; A61K31/4436 ; A61K45/06 ; C07D513/04 ; C07D405/14 ; C07D401/04 ; C07D413/04 ; C07D417/04 ; C07D417/14 ; C07D403/04 ; C07D401/14
Abstract:
The present invention relates to compounds which modulate interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or treatment of inflammatory, cell proliferative and immune-related conditions and diseases. Specifically, provided herein are inhibitors of IRAK4 of Formula I and pharmaceutical compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
Public/Granted literature
- US20150299224A1 INHIBITORS OF IRAK4 ACTIVITY Public/Granted day:2015-10-22
Information query
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