Invention Grant
- Patent Title: Isolated polypeptide of the toxin A and toxin B proteins of C. difficile and uses thereof
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Application No.: US14342565Application Date: 2011-09-05
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Publication No.: US09598472B2Publication Date: 2017-03-21
- Inventor: Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
- Applicant: Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
- Applicant Address: AT Vienna US MD Gaithersburg
- Assignee: Valneva Austria GmbH,Intercell USA, Inc.
- Current Assignee: Valneva Austria GmbH,Intercell USA, Inc.
- Current Assignee Address: AT Vienna US MD Gaithersburg
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/EP2011/065304 WO 20110905
- International Announcement: WO2012/028741 WO 20120308
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/02 ; C07K14/33 ; A61K39/08 ; C07K16/12
Abstract:
This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
Public/Granted literature
- US20150056238A1 ISOLATED POLYPEPTIDE OF THE TOXIN A AND TOXIN B PROTEINS OF C. DIFFICILE AND USES THEREOF Public/Granted day:2015-02-26
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