Invention Grant
- Patent Title: Nanoparticle-peptide compositions
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Application No.: US14343083Application Date: 2012-09-07
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Publication No.: US09598479B2Publication Date: 2017-03-21
- Inventor: Thomas Rademacher , Phillip Williams
- Applicant: Thomas Rademacher , Phillip Williams
- Applicant Address: GB Abingdon, Oxfordshire
- Assignee: Midatech Ltd.
- Current Assignee: Midatech Ltd.
- Current Assignee Address: GB Abingdon, Oxfordshire
- Agency: Dann, Dorfman, Herrell and Skillman
- Agent Patrick J. Hagan
- International Application: PCT/EP2012/067561 WO 20120907
- International Announcement: WO2013/034126 WO 20130314
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C07K14/47 ; C07K7/06 ; C07K7/08 ; C07K14/77 ; A61K38/38 ; A61K39/00

Abstract:
The present invention provides nanoparticles and compositions comprising such nanoparticles, as well as methods for intracellular delivery of peptides, and methods of producing nanoparticles and related products. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker. The second linker comprises a peptide portion and a non-peptide portion, wherein said peptide portion of said second linker comprises the sequence X1X2Z1, wherein: X1 is an amino acid selected from A and G; X2 is an amino acid selected from A and G; and Z1 is an amino acid selected from Y and F.
Public/Granted literature
- US20140341938A1 NANOPARTICLE-PEPTIDE COMPOSITIONS Public/Granted day:2014-11-20
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