Invention Grant
- Patent Title: Human alpha-folate receptor chimeric antigen receptor
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Application No.: US14432664Application Date: 2013-10-03
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Publication No.: US09598489B2Publication Date: 2017-03-21
- Inventor: Daniel J. Powell, Jr.
- Applicant: The Trustees of the University of Pennsylvania
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the Univeristy of Pennsylvania
- Current Assignee: The Trustees of the Univeristy of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing LLP
- Agent Kathryn Doyle
- International Application: PCT/US2013/063282 WO 20131003
- International Announcement: WO2014/055771 WO 20140410
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12N5/07 ; C12N5/071 ; C12P21/04 ; C07H21/04 ; C07K1/00 ; C07K16/28
Abstract:
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having alpha-folate receptor (FR-alpha) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FR-alpha binding domain is fully human, thereby preventing a host immune response.
Public/Granted literature
- US20150225480A1 HUMAN ALPHA-FOLATE RECEPTOR CHIMERIC ANTIGEN RECEPTOR Public/Granted day:2015-08-13
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