Invention Grant
- Patent Title: RSPO3 binding agents and uses thereof
-
Application No.: US14870145Application Date: 2015-09-30
-
Publication No.: US09598497B2Publication Date: 2017-03-21
- Inventor: Austin L. Gurney , Christopher J. Bond
- Applicant: OncoMed Pharmaceuticals, Inc.
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein and Fox, P.L.L.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/30 ; C07K16/18 ; A61K45/06 ; C12Q1/68 ; C07K16/24 ; A61K39/00
Abstract:
The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate β-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO3 proteins and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
Public/Granted literature
- US20160108130A1 RSPO3 Binding Agents and Uses Thereof Public/Granted day:2016-04-21
Information query
