Invention Grant
- Patent Title: Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
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Application No.: US14004379Application Date: 2012-03-12
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Publication No.: US09598703B2Publication Date: 2017-03-21
- Inventor: Luis Garcia , Cyriaque Beley , Thomas Voit , Robert Michael Kotin , Lina Li
- Applicant: Luis Garcia , Cyriaque Beley , Thomas Voit , Robert Michael Kotin , Lina Li
- Applicant Address: FR US DC Washington
- Assignee: ASSOCIATION INSTITUT DE MYOLOGIE; UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ DE LAD RECHERCHE MÉDICALE,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH
- Current Assignee: ASSOCIATION INSTITUT DE MYOLOGIE; UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ DE LAD RECHERCHE MÉDICALE,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH
- Current Assignee Address: FR US DC Washington
- Agency: Leason Ellis LLP
- Priority: EP11157986 20110312
- International Application: PCT/EP2012/054303 WO 20120312
- International Announcement: WO2012/123430 WO 20120920
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K35/12 ; A61N1/30 ; C12N15/86
Abstract:
An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.
Public/Granted literature
- US20140107186A1 CAPSID-FREE AAV VECTORS, COMPOSITIONS, AND METHODS FOR VECTOR PRODUCTION AND GENE DELIVERY Public/Granted day:2014-04-17
Information query
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