Invention Grant
- Patent Title: Quantification of misfolded TNFR2:Fc
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Application No.: US14455183Application Date: 2014-08-08
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Publication No.: US09598718B2Publication Date: 2017-03-21
- Inventor: Alfred Rupprechter , Michael Fuchs , Johann Holzmann , William Lamanna , Christoph Posch , Hansjorg Toll , Robert Mayer
- Applicant: Sandoz AG
- Applicant Address: CH Basel
- Assignee: Sandoz AG
- Current Assignee: Sandoz AG
- Current Assignee Address: CH Basel
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: EP14177696 20140718
- Main IPC: G01N21/33
- IPC: G01N21/33 ; C12Q1/37 ; G01N33/68 ; C07K14/715
Abstract:
The present invention is directed to methods for determining the relative amount of wrongly disulphide bridged TNFR2:Fc in a sample of TNFR2:Fc, a fusion protein which is used in a variety of therapeutic applications. In addition, the invention pertains to a method for purifying TNFR2:Fc using said method for determining the percentage of wrongly disulphide bridged TNFR2:Fc, and to TNFR2:Fc compositions obtained thereby.
Public/Granted literature
- US20160017403A1 QUANTIFICATION OF MISFOLDED TNFR2:FC Public/Granted day:2016-01-21
Information query
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