Invention Grant
- Patent Title: Methods for identifying subjects with a genetic risk for developing IgA nephropathy
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Application No.: US14000328Application Date: 2012-02-17
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Publication No.: US09598733B2Publication Date: 2017-03-21
- Inventor: Ali Gharvari , Krzysztof Kiryluk , Richard Lifton
- Applicant: Ali Gharvari , Krzysztof Kiryluk , Richard Lifton
- Applicant Address: US NY New York US CT New Haven
- Assignee: The Trustees of Columbia University in the City of New York,Yale University
- Current Assignee: The Trustees of Columbia University in the City of New York,Yale University
- Current Assignee Address: US NY New York US CT New Haven
- Agency: Beusse Wolter Sanks & Maire PLLC
- Agent Judith A. Evans; Timothy H. Van Dyke
- International Application: PCT/US2012/025742 WO 20120217
- International Announcement: WO2012/112955 WO 20120823
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/11 ; A61K48/00 ; C12Q1/68
Abstract:
Seven protective alleles for IgA nephropathy have been discovered that can be identified by analyzing a DNA sample for seven respective SNPs. A method is provided for identifying and treating subjects at risk of developing IgA neuropathy based on a new seven-SNP genetic risk score. Also provided are screening methods to identify compounds that bind to and reduce the expression or biological activity of a either CFHR1 or CFHR3.
Public/Granted literature
- US20140039036A1 Methods for Identifying Subjects with a Genetic Risk for Developing IgA Nephropathy Public/Granted day:2014-02-06
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