In a method for operating an internal combustion engine a compression ratio is set to a setpoint compression ratio by means of an adjustment device, wherein in a normal operating mode of the internal combustion engine the setpoint compression ratio is determined as a function of an, operating variable of the internal combustion engine. The internal combustion engine is at least temporarily operated in a predictive operating mode in which the setpoint compression ratio is determined on the basis of an anticipated estimated operating variable which is estimated on the basis of the instantaneous gradient of the operating variable over time.