In a method and control sequence determination device for determination of a magnetic resonance system control sequence to generate an image series of a defined image region of an examination subject, the control sequence includes a multichannel pulse train with multiple individual RF pulse trains to be emitted in parallel by the magnetic resonance system via different independent radio-frequency transmission channels. The multichannel pulse train includes an excitation pulse to excite the image region and a subsequent number of refocusing pulses in order to respectively excite an echo signal to acquire raw data for an image of the image series. At least one defined marking region in the image region is determined depending on a subject structure to be depicted in the image region, and the multichannel pulse train is determined such that a saturation is achieved at or in the marking regions before the excitation pulse.