A logic block addressing (LBA) configuration method and a non-volatile memory device having the same are provided. The non-volatile memory device determines one of logic zones configured in an LBA table according to the number of booting times. The selected logic zone corresponds to a data zone configured in a physical volume. The non-volatile memory device accesses data stored in the data zone in the selected logic zone. Accordingly, in each boot, the instant disclosure provides the LBA configuration method and the non-volatile memory device having the same, which can show data stored in the different data zones of the physical volume to simplify user operation and avoid the user maliciously destroying or erroneously deleting other data stored in the unused data zones of the physical volume, thereby enhancing the efficiency of the non-volatile memory device executing the multi-booting.