A monitoring system may include each of a left and a right side EMG detection device and may be configured to detect either seizure activity associated with the left side or right side of a patient's body. The system may further be configured to differentiate symmetric or asymmetric seizure activity. For example, the system may characterize whether left and right side EMG detectors show similar or dissimilar levels of activation during a suspected seizure. In some embodiments, the system may also include one or more orientation and/or position sensors. The system may be configured to determine the orientation and position of the sensor over time and to correlate this data with EMG signals.