A vitrectomy probe for removing vitreous material from an eyeball, having a longitudinal axis and an outer tube with a closed end and a lateral surface, at least one inlet port located proximate to the closed end and configured to allow the vitreous material to enter into the outer tube; an inner tube arranged in the outer tube to relatively move with respect to the outer tube, the inner tube having an opening with a cutting profile through which the vitreous material can be cut and can enter the inner tube. A drive unit configured for causing the outer tube and the inner tube to move relatively with respect to each other, in such a way that the cutting profile cuts the vitreous material entering the inlet port.