Invention Grant
- Patent Title: Substituted aminobutyric derivatives as neprilysin inhibitors
-
Application No.: US14635311Application Date: 2015-03-02
-
Publication No.: US09603819B2Publication Date: 2017-03-28
- Inventor: Gary Mark Coppola , Yuki Iwaki , Rajeshri Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Sophie Binet Cross
- Main IPC: A61K31/194
- IPC: A61K31/194 ; C07C233/47 ; C07C233/63 ; C07C233/87 ; C07C235/52 ; C07C251/12 ; C07C257/06 ; C07C271/12 ; C07C275/16 ; C07C311/19 ; C07C317/44 ; C07C235/82 ; C07D207/34 ; C07D209/18 ; C07D213/56 ; C07D213/81 ; C07D213/82 ; C07D231/14 ; C07D239/28 ; C07D271/10 ; C07D277/64 ; C07D285/12 ; C07D303/48 ; C07D307/68 ; C07D309/40 ; C07D333/24 ; C07D333/40 ; C07D261/18 ; A61K45/06 ; C07C235/74
Abstract:
The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Public/Granted literature
- US20150174089A1 SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS Public/Granted day:2015-06-25
Information query
IPC分类:
