Invention Grant
- Patent Title: Compositions comprising TL1A-Ig fusion protein for the regulation of T regulatory cells, and methods for their use
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Application No.: US14185295Application Date: 2014-02-20
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Publication No.: US09603925B2Publication Date: 2017-03-28
- Inventor: Eckhard R. Podack , Taylor H. Schreiber , Samia Q. Khan
- Applicant: University of Miami
- Applicant Address: US FL Miami
- Assignee: University of Miami
- Current Assignee: University of Miami
- Current Assignee Address: US FL Miami
- Agency: Fish & Richardson P.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K14/52 ; C07K14/525 ; A61K31/436 ; A61K38/20 ; C07K14/55 ; A61K47/48 ; A61K31/7088 ; C07K16/24
Abstract:
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also described are combination therapies that include the administration of a TNFRSF25 agonist and an interleukin (e.g., IL-2) and/or an mTOR inhibitor (e.g., rapamycin).
Public/Granted literature
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