Invention Grant
- Patent Title: Peptide sequence design and use thereof for peptide-mediated siRNA delivery
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Application No.: US14983194Application Date: 2015-12-29
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Publication No.: US09603946B2Publication Date: 2017-03-28
- Inventor: Pu Chen , Mousa Jafari , Wen Xu , Baoling Chen , Ran Pan , Nedra Karunaratne
- Applicant: Positec Power Tools (Suzhou) Co Ltd , Pu Chen
- Applicant Address: CN Jiangsu Province CA Waterloo, Ontario
- Assignee: Positec Power Tools (Suzhou) Co LTD,Pu Chen
- Current Assignee: Positec Power Tools (Suzhou) Co LTD,Pu Chen
- Current Assignee Address: CN Jiangsu Province CA Waterloo, Ontario
- Agency: Dunlap Codding, P.C.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; A61K47/48 ; A61K31/713 ; C12N15/87 ; C07K14/47 ; C12N15/11 ; C07K19/00 ; C12N15/113 ; A61K9/00 ; A61K9/08 ; A61K38/00
Abstract:
Peptides that have been found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets are disclosed. Complexes that include one of the peptides and a cargo molecule are disclosed, wherein the peptide and the cargo molecule are coupled non-covalently. Also disclosed are methods of producing and using the peptides/complexes.
Public/Granted literature
- US20160175456A1 Peptide Sequence Design and Use Thereof For Peptide-Mediated siRNA Delivery Public/Granted day:2016-06-23
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