In various embodiments, a surgical system is disclosed. The surgical system comprises a medicament and a surgical instrument comprising a plurality of staples, a cavity configured to store the medicament, a delivery passage configured to convey the medicament from the cavity to tissue, and a firing system. The firing system comprises a movable member and a firing member, wherein the firing system is configured to cooperatively move the movable member and the firing member to concurrently fire the plurality of staples and deliver at least a portion of the medicament to the tissue owing to advancement of the firing member.