Invention Grant
- Patent Title: Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
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Application No.: US13789005Application Date: 2013-03-07
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Publication No.: US09604916B2Publication Date: 2017-03-28
- Inventor: James T. Dalton , Mitchell S. Steiner , Ramesh Narayanan , Sunjoo Ahn
- Applicant: GTx, Inc.
- Applicant Address: US TN Memphis
- Assignee: GTX, INC.
- Current Assignee: GTX, INC.
- Current Assignee Address: US TN Memphis
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- Main IPC: A61K31/167
- IPC: A61K31/167 ; C07C271/02 ; A61K31/325 ; A61K45/06

Abstract:
This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of: a) treating a subject suffering from breast cancer; b) treating a subject suffering from metastatic breast cancer; c) treating a subject suffering from refractory breast cancer; d) treating a subject suffering from AR-positive breast cancer; e) treating a subject suffering from AR-positive refractory breast cancer; f) treating a subject suffering from AR-positive metastatic breast cancer; g) treating a subject suffering from AR-positive and ER-positive breast cancer; h) treating a subject suffering from triple negative breast cancer; i) treating a subject suffering from advanced breast cancer; j) treating a subject suffering from breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; k) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer; l) prolonging survival of a subject with breast cancer, and/or m) prolonging the progression-free survival of a subject with breast cancer; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound, comprising administering to the subject a therapeutically effective amount of a SARM compound of this invention.
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